Pneumologie 1999; 53(9): 454-458
DOI: 10.1055/s-1999-9035
ÜBERSICHT
Georg Thieme Verlag Stuttgart ·New York

Gentoxizität von Asbestfasern - eine Literaturauswertung

B. Marczynski, P. Rozynek, H. Huber, X. Baur
  • Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin (BGFA) (Prof. Dr. med. X. Baur), Institut an der Ruhr-Universität Bochum
Further Information

Publication History

Publication Date:
31 December 1999 (online)

Also available at
 

Zusammenfassung:

Asbestfasern rufen DNA- und Chromosomenschäden hervor. Diese Genomveränderungen gehen offensichtlich ebenso wie Lipidperoxidation und oxidative Proteinschädigungen auf die Bildung reaktiver Sauerstoffspezies (RSS) zurück. RSS entstehen sowohl bei einer Redox-Reaktion an der Faseroberfläche als auch in der Zelle. Der Mechanismus der Fasergentoxizität ist von der chemischen Zusammensetzung der Faser sowie der Faserstruktur und der Faserdimension abhängig. Eine Schädigung der zellulären DNA kann durch Oxidoreduktionsprozesse, die in den Zellen während der Phagozytose ablaufen, hervorgerufen werden. Darüber hinaus wird die genetische Instabilität erhöht, wenn genetisch veränderte Zellen durch externe mitogene Faktoren stimuliert werden, sich zu vermehren. Faserinduzierte DNA-Schädigungen unterliegen Reparaturmechanismen.

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Dr. B. Marczynski

BGFA Institut an der Ruhr-Universität Bochum

Bürkle-de-la-Camp-Platz 1

44789 Bochum

Email: marczynski@bgfa.ruhr-universität-bochum.de