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Am J Perinatol 2000; Volume 17(Number 05): 249-252
DOI: 10.1055/s-2000-10006
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

TRANSIENT RENAL TUBULAR ACIDOSIS IN PREGNANCY

Muhieddine Seoud, Abdallah Adra, Ali Khalil, Rana Skaff, Ihab Usta, Ibrahim Salti
  • Department of Obstetrics & Gynecology and Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

Renal tubular acidosis in pregnancy is a very rare disorder. Most cases are either inherited or secondary to maternal disease or ingestion of toxic chemicals. We report a 22-year-old woman, previously healthy, who presented at 27 weeks of gestation with preterm labor. Investigation revealed renal tubular acidosis with no obvious etiology. Labor was stopped with various tocolytic drugs and her electrolyte imbalance was corrected. She was delivered at 36 weeks, by cesarean for a nonreassuring fetal heart tracing, of an appropriate-for-gestational-age infant weighing 2905 g. Evaluation 3 and 6 months postpartum revealed gradual, but complete resolution of the acidosis and electrolyte abnormality. The infant is now 7 months old, is growing normally with normal electrolytes, and with no evidence of acidosis.

KEYWORD

Tubular acidosis - pregnancy - transient

REFERENCES

  • 1 Caruana R J, Buckalew V M. The syndrome of distal (type 1) renal tubular acidosis: clinical and laboratory findings in 58 cases.  Medicine . 1988;  67 84-99
    PubMedGoogle Scholar
  • 2 Goodwin T M. Toluene abuse and renal tubular acidosis in pregnancy.  Obstet Gynecol . 1988;  71 715-718
    PubMedGoogle Scholar
  • 3 Wilkins-Haug L, Gabow P A. Toluene abuse during pregnancy: obstetric complications and perinatal outcomes.  Obstet Gynecol . 1991;  77 504-508
    PubMedGoogle Scholar
  • 4 Seedat Y K, Raine M B. Active chronic hepatitis associated with renal tubular acidosis and successful pregnancy.  S Afr Med J . 1965;  39 595-597
    PubMedGoogle Scholar
  • 5 Giammarco R, Cowel G. Renal tubular acidosis during therapy for diabetic ketoacidosis.  Can Med Assoc . 1975;  112 463-466
    PubMedGoogle Scholar
  • 6 Patterson R M, Ackerman G L. Renal tubular acidosis due to amphotericin-B nephritoxicity.  Arch Intern Med . 1971;  127 241-244
    CrossrefPubMedGoogle Scholar
  • 7 Szwed J J, Clarke M. Case report: renal tubular acidosis in pregnancy.  Am J Med Sci . 1982;  284 32-36
    PubMedGoogle Scholar
  • 8 Cheng C Y, Nair V, Salmon Y. Renal tubular acidosis presenting in pregnancy with severe hypokalemia.  Aust N Z J Obstet Gynecol . 1983;  23 117-119
    PubMedGoogle Scholar
  • 9 Hardardottir H, Lahiri T, Egan J FX. Renal tubular acidosis in pregnancy: case report and literature review.  J Matern Fetal Med . 1997;  6 16-20
    CrossrefPubMedGoogle Scholar
  • 10 Blechner J N, Stenger V G, Prystowsky H. Blood flow to the human uterus during maternal metabolic acidosis.  Am J Obstet Gynecol . 1975;  121 789-793
    PubMedGoogle Scholar
  • 11 Buckalew V M, Puris M L, Shulman MG et al. Hereditary renal tubular acidosis.  Medicine . 1974;  53 229-252
    PubMedGoogle Scholar
  • 12 Churchill J A, Berendes H W, Nemore J. Neuropsychological deficits in children of diabetic mothers.  Am J Obstet Gynecol . 1969;  105 257-268
    PubMedGoogle Scholar
  • 13 Savani R C, Mimouni F, Tsang R C. Maternal and neonatal hyperparathyroidism as a consequence of maternal renal tubular acidosis.  Pediatrics . 1993;  91 661-663
    PubMedGoogle Scholar