Three New Lanostane-Type Triterpene Lactones from the Stem Bark of Abies mariesii

Abstract

Three new Δ⁸-lanostane-type triterpene lactones (1), (2) and (3) were isolated from the stem bark of Abies mariesii M. and unambiguously characterized on the basis of spectroscopic and chemical evidence. Chemical modification of compound 1 showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).

Key words

Abies mariesii - Pinaceae - lanostane - 2D NMR - in vitro anti-tumor-promoting activity

References

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