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Semin Liver Dis 2000; 20(4): 511-522
DOI: 10.1055/s-2000-13159
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Prospects for Xenotransplantation of the Liver

Akiyoshi Kanazawa1 , Jeffrey L. Platt2
  • Departments of Surgery and Immunology,
  • 1 Mayo Clinic, Rochester, Minnesota and Departments of Surgery and Pediatrics
  • 2, Mayo Clinic, Rochester, Minnesota. Reprint request: Dr. Jeffrey L. Platt, Transplantation Biology, 2-66 Medical Sciences Building, Mayo Clinic, 200 First Street Southwest, Rochester, Minnesota 55905. E-mail: platt.jeffrey@mayo.edu
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

A severe shortage of human livers for allotransplantation has sparked interest in the potential use of animals in lieu of humans as a source of livers, that is xenotransplantation. Xenotransplantation might also provide a means by which recurrence of hepatitis might be averted. Among the types of xenografts that might be undertaken are extracorporeal ``xenoperfusion'' or perfusion of devices containing xenogeneic hepatocytes, auxiliary liver transplants, bridge liver transplants, and hepatocyte transplants. The hurdles to xenotransplantation of the liver include the immune response of the recipient against the graft, incompatibility of the graft with complex physiologic and biochemical systems of the recipient, and the possibility of transferring infectious agent from the graft to the recipient. Recent progress in characterizing and overcoming these hurdles has encouraged some optimism regarding the ultimate application of xenotransplantation for the treatment of human disease.

KEYWORD

xenotransplantation - liver - immunology

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