Hereditary and Acquired Thrombophilia

Ivan Bank; Saskia Middeldorp; Harry R. Büller

doi:10.1055/s-2000-13190

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2000; 21(6): 467-476
DOI: 10.1055/s-2000-13190

Hereditary and Acquired Thrombophilia

Ivan Bank, Saskia Middeldorp, Harry R. Büller

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands

Abstract

ABSTRACT

During the past decade knowledge about the etiology of venous thromboembolism has increased tremendously. Inherited and acquired risk factors for venous thromboembolism are common in patients as well as in the general population. Whether the presence of most of these risk factors has consequences for the management of symptomatic and asymptomatic individuals is not fully clear at present. Therefore, while searching for new thrombophilic defects, it is crucial to determine the absolute risk for (recurrent) venous thromboembolism as well as other clinical manifestations in carriers. However, tentative guidelines for managing patients and their families are given in this review.

KEYWORD

Thrombophilia - venous thromboembolism - risk factors - etiology - epidemiology

Full Text

References

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