Endoscopy 2000; 32(1): 37-41
DOI: 10.1055/s-2000-133
Original Article
Georg Thieme Verlag Stuttgart ·New York

A Blinded, Randomized Comparison of a Novel, Low-Dose, Triple Regimen with Fleet Phospho-Soda: A Study of Colon Cleanliness, Speed and Success of Colonoscopy

A. P. Chilton, M. O'Sullivan, M. A. Cox, D. E. Loft, C. U. Nwokolo
  • Walsgrave Hospital, Coventry, UK
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Publikationsverlauf

Publikationsdatum:
25. September 2003 (online)

Background and Study Aims: A clean colon is essential for an efficient examination. The aim of this study was to compare a novel low-dose, low volume triple regimen with Fleet Phospho-soda.

Methods: A blinded, experienced colonoscopist examined 132 consecutive patients randomly allocated to receive either a triple regimen consisting of senna syrup (sennoside B), Picolax (sodium picosulphate), and Klean Prep (polyethylene glycol 3350), or Fleet Phospho-soda (sodium dihydrogen phosphate and disodium phosphate dodecahydrate). The colonoscopist recorded cleanliness according to a scoring system (1 - very clean to 4 - solid stools), and time taken to reach the caecum.

Results: In the triple regimen group (n = 81), 73 % scored 1 or 2 compared with 57 % in the Fleet Phospho-soda group (n = 51, p = 0.037 Mann-Whitney U-test). Examination to caecum was achieved in 95 % of the triple regimen group and 89 % of the Fleet Phospho-soda group. Among those examined as far as the caecum, the time to reach the caecum was 11 minutes (range 5 - 50) in the triple regimen group compared with 16 minutes (range 5 - 65) in the Fleet Phospho-soda group (p = 0.08, Mann-Whitney U-test). Patient tolerability was not assessed in this study.

Conclusions: This novel triple regimen produces a cleaner colon than Fleet Phospho-soda, is associated with a trend towards a quicker and more efficient colonic examination, and is also 30 % cheaper per patient.

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F.R.C.P.E. F.R.C.P. M.D. C. U. Nwokolo

Walsgrave Hospital Clifford Bridge Road

Coventry CV2 2DX

United Kingdom

Telefon: +44-1203-538793

eMail: ChukaNwokolo@compuserve.com