Download PDF
Endoscopy 2000; 32(2): 131-137
DOI: 10.1055/s-2000-142
State-of-the-Art Review
Georg Thieme Verlag Stuttgart · New York

Inflammatory Bowel Disease

P. Marteau
  • Dept. of Gastroenterology, Laennec Hospital, Assistance Publique des Hôpitaux de Paris, and University of Paris V, Paris, France
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Also available at
    Permissions and Reprints

This article reviews important papers on inflammatory bowel disease published between May 1998 and June 1999. It does not review every aspect of treatment, but focuses on the effects of anti-tumor necrosis factor antibodies on the inflammatory lesions. The new information summarized includes: the role of bacteria and the modulating effects of probiotics; the frequency of appendiceal orifice inflammation in ulcerative colitis; progress in imaging based on endoscopic ultrasonography, magnetic resonance imaging, and leukocyte scintigraphy; frequency and treatment of massive hemorrhage, viral superinfection, and persistent perineal sinus; and the pathogenesis, detection, and treatment of dysplasia and cancer.

References (Key References are highlighted)

  • 1 Schölmerich J. Inflammatory bowel disease.  Endoscopy. 1999;  31 66-73
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Hugot  JP, Zouali H, Lesage S, Thomas G. Etiology of the inflammatory bowel diseases.  Int J Colorectal Dis. 1999;  14 2-9
    CrossrefPubMedGoogle Scholar
  • 3 Darfeuille-Michaud A, Neut C, Barnich N, et al. Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease.  Gastroenterology. 1998;  115 1405-1413
    PubMedGoogle Scholar
  • 4 Walmsley RS, Anthony A, Sim R, et al. Absence of Escherichia coli, Listeria monocytogenes, and Klebsiella pneumoniae antigens within inflammatory bowel disease tissues.  J Clin Pathol. 1998;  51 657-661
    PubMedGoogle Scholar
  • 5 Tiveljung A, Soderholm JD, Olaison G, et al. Presence of eubacteria in biopsies from Crohn's disease inflammatory lesions as determined by 16S rRNA gene-based PCR.  J Med Microbiol. 1999;  48 263-268
    PubMedGoogle Scholar
  • 6 Madsen KL, Doyle JS, Jewell LD, et al. Lactobacillus species prevent colitis in interleukin 10 gene-deficient mice.  Gastroenterology. 1999;  116 1107-1114
    PubMedGoogle Scholar
  • 7 Campieri  M, Gionchetti P. Probiotics in inflammatory bowel disease: new insight to pathogenesis or a possible therapeutic alternative?.  Gastroenterology. 1999;  116 1246-1249
    CrossrefPubMedGoogle Scholar
  • 8 Okawa K, Aoki T, Sano K, et al. Ulcerative colitis with skip lesions at the mouth of the appendix: a clinical study.  Am J Gastroenterol. 1998;  93 2405-2410
    CrossrefPubMedGoogle Scholar
  • 9 Yang SK, Jung HY, Kang GH, et al. Appendiceal orifice inflammation as a skip lesion in ulcerative colitis: an analysis in relation to medical therapy and disease extent.  Gastrointest Endosc. 1999;  49 743-747
    CrossrefPubMedGoogle Scholar
  • 10 Tribl B, Turetschek K, Mostbeck G, et al. Conflicting results of ileoscopy and small bowel double-contrast barium examination in patients with Crohn's disease.  Endoscopy. 1998;  30 339-344
    PubMedGoogle Scholar
  • 11 Tsang  P, Rotterdam H. Biopsy diagnosis of colitis: possibilities and pitfalls.  Am J Surg Pathol. 1999;  23 423-430
    CrossrefPubMedGoogle Scholar
  • 12 Dagli U, Over H, Tezel A, et al. Transrectal ultrasound in the diagnosis and management of inflammatory bowel disease.  Endoscopy. 1999;  31 152-157
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Gast  P, Belaïche J. Rectal endosonography in inflammatory bowel disease: differential diagnosis and prediction of remission.  Endoscopy. 1999;  31 158-166
    Article in Thieme ConnectPubMedGoogle Scholar
  • 14 Gast P. Endorectal ultrasound in infectious colitis may predict development of chronic colitis.  Endoscopy. 1999;  31 265-268
    Article in Thieme ConnectPubMedGoogle Scholar
  • 15 Tsuga K, Haruma K, Fujimura J, et al. Evaluation of the colorectal wall in normal subjects and patients with ulcerative colitis using an ultrasonic catheter probe.  Gastrointest Endosc. 1998;  48 477-484
    PubMedGoogle Scholar
  • 16 Soweid AM, Chak A, Katz JA, et al. Catheter probe-assisted endoluminal US in inflammatory bowel disease.  Gastrointest Endosc. 1999;  50 41-46
    PubMedGoogle Scholar
  • 17 Orsoni P, Barthet M, Portier F, et al. Prospective comparison of endosonography, magnetic resonance imaging and surgical findings in anorectal fistula and abscess complicating Crohn's disease.  Br J Surg. 1999;  86 360-364
    CrossrefPubMedGoogle Scholar
  • 18 Madsen SM, Thomsen HS, Munkholm P, et al. Active Crohn's disease and ulcerative colitis evaluated by low-field magnetic resonance imaging.  Scand J Gastroenterol. 1998;  33 1193-1200
    CrossrefPubMedGoogle Scholar
  • 19 Guimbaud  R, Beades E, Chauvelot-Moachon L, et al. Technetium Tc-99m hexamethyl propylene amine oxine leukocyte scintigraphy in patients with ulcerative colitis: correlation with clinical, biologic, endoscopic, and pathologic intensity, and local release of interleukin 8.  Gastrointest Endosc. 1998;  48 491-496
    PubMedGoogle Scholar
  • 20 Aburano T, Saito Y, Shuke N, et al. Tc-99m leukocyte imaging for evaluating disease severity and monitoring treatment response in ulcerative colitis: comparison with colonoscopy.  Clin Nucl Med. 1998;  23 509-513
    CrossrefPubMedGoogle Scholar
  • 21 Sans M, Llach J, Bordas JM, et al. Life-threatening hemorrhage: an unusual form of presentation of Crohn's disease treated with endoscopic injection sclerotherapy.  Endoscopy. 1998;  30 S83-S84
    PubMedGoogle Scholar
  • 22 Pardi DS, Loftus EV Jr, Tremaine WJ, et al. Acute major gastrointestinal hemorrhage in inflammatory bowel disease.  Gastrointest Endosc. 1999;  49 153-157
    CrossrefPubMedGoogle Scholar
  • 23 Dijkstra B, Bagshaw PF, Frizelle FA. Protective effect of appendectomy on the development of ulcerative colitis: matched, case-control study.  Dis Colon Rectum. 1999;  42 334-336
    PubMedGoogle Scholar
  • 24 Moum B, Ekbom A, Vatn MH, Elgjo K. Change in the extent of colonoscopic and histological involvement in ulcerative colitis over time.  Am J Gastroenterol. 1999;  94 1564-1569
    CrossrefPubMedGoogle Scholar
  • 25 Yamamoto T, Bain IM, Allan RN, Keighley MR. Persistent perineal sinus after proctocolectomy for Crohn's disease.  Dis Colon Rectum. 1999;  42 96-101
    CrossrefPubMedGoogle Scholar
  • 26 Yamamoto  T, Keighley RB. Long-term outcome of total colectomy and ileostomy for Crohn disease.  Scand J Gastroenterol. 1999;  34 280-286
    CrossrefPubMedGoogle Scholar
  • 27 Lautenbach E, Berlin JA, Lichtenstein GR. Risk factors for early postoperative recurrence of Crohn's disease.  Gastroenterology. 1998;  115 259-267
    PubMedGoogle Scholar
  • 28 Tillinger W, Mittermaier C, Lochs H, Moser G. Health-related quality of life in patients with Crohn's disease - influence of surgical operation: a prospective trial.  Dig Dis Sci. 1999;  44 932-938
    CrossrefPubMedGoogle Scholar
  • 29 Tiainen J, Matikainen M, Hiltunen KM. Ileal J-pouch: anal anastomosis, sexual dysfunction, and fertility.  Scand J Gastroenterol. 1999;  34 185-188
    CrossrefPubMedGoogle Scholar
  • 30 Sarigol  S, Wyllie R, Gramlich T, et al. Incidence of dysplasia in pelvic pouches in pediatric patients after ileal pouch-anal anastomosis for ulcerative colitis. .  J Pediatr Gastroenterol Nutr. 1999;  28 429-434
    CrossrefPubMedGoogle Scholar
  • 31 Vega  R, Bertran X, Menacho M, et al. Cytomegalovirus infection in patients with inflammatory bowel disease.  Am J Gastroenterol. 1999;  94 1053-1056
    CrossrefPubMedGoogle Scholar
  • 32 Kaufman  HS, Kahn AC, Iacobuzio-Donahue C, et al. Cytomegaloviral enterocolitis: clinical associations and outcome.  Dis Colon Rectum. 1999;  42 24-30
    CrossrefPubMedGoogle Scholar
  • 33 Yanai H, Shimizu N, Nagasaki S, et al. Epstein-Barr virus infection of the colon with inflammatory bowel disease.  Am J Gastroenterol. 1999;  94 1582-1586
    CrossrefPubMedGoogle Scholar
  • 34 Karlen P, Lofberg R, Brostrom O, et al. Increased risk of cancer in ulcerative colitis: a population-based cohort study.  Am J Gastroenterol. 1999;  94 1047-1052
    PubMedGoogle Scholar
  • 35 Shetty K, Rybicki L, Brzezinski A, et al. The risk for cancer or dysplasia in ulcerative colitis patients with primary sclerosing cholangitis.  Am J Gastroenterol. 1999;  94 1643-1649
    CrossrefPubMedGoogle Scholar
  • 36 Nuako  KW, Ahlquist DA, Mahoney DW, et al. Familial predisposition for colorectal cancer in chronic ulcerative colitis: a case-control study.  Gastroenterology. 1999;  115 1079-1083
    PubMedGoogle Scholar
  • 37 Chan JL, Tersmette AC, Offerhaus GJ, et al. Cancer risk in collagenous colitis.  Inflamm Bowel Dis. 1999;  5 40-43
    PubMedGoogle Scholar
  • 38 Sigel JE, Petras RE, Lashner BA, et al. Intestinal adenocarcinoma in Crohn's disease: a report of 30 cases with a focus on coexisting dysplasia.  Am J Surg Pathol. 1999;  23 651-655
    CrossrefPubMedGoogle Scholar
  • 39 Green S, Stock RG, Greenstein AJ. Rectal cancer and inflammatory bowel disease: natural history and implications for radiation therapy.  Int J Radiat Oncol Biol Phys. 1999;  44 835-840
    CrossrefPubMedGoogle Scholar
  • 40 Willenbucher  RF, Aust DE, Chang CG, et al. Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia.  Am J Pathol. 1999;  154 1825-1830
    PubMedGoogle Scholar
  • 41 Brand S, Stepp H, Ochsenkuhn TH, et al. Detection of colonic dysplasia by light-induced fluorescence endoscopy: a pilot study.  Int J Colorectal Dis. 1999;  14 63-68
    CrossrefPubMedGoogle Scholar
  • 42 Lang SM, Stratakis DF, Heinzlmann M, et al. Molecular screening of patients with long standing extensive ulcerative colitis: detection of p53 and Ki-ras mutations by single strand conformation polymorphism analysis and differential hybridisation in colonic lavage fluid.  Gut. 1999;  44 822-825
    PubMedGoogle Scholar
  • 43 D'Haens  G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: a European multicenter trial.  Gastroenterology. 1999;  116 1029-1034
    PubMedGoogle Scholar
  • 44 Present  DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease.  N Engl J Med. 1999;  340 1398-1405
    CrossrefPubMedGoogle Scholar
  • 45 Aitola P, Hiltunen KM, Matikainen M. Fibrin glue in perianal fistulas: a pilot study.  Ann Chir Gynaecol. 1999;  88 136-138
    PubMedGoogle Scholar
  • 46 Canin-Endres J, Salky B, Gattorno F, Edye M. Laparoscopically assisted intestinal resection in 88 patients with Crohn's disease.  Surg Endosc. 1999;  13 595-599
    CrossrefPubMedGoogle Scholar

P. MarteauM.D. 

Hôpital Laennec

Service de Gastro-Entérologie

42, rue de Sèvres

75007 Paris

France

Phone: + 33-1-44396799

Email: philippe.marteau@lnc.ap-hop-paris.fr