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Planta Med 2000; 66(4): 384-385
DOI: 10.1055/s-2000-14898
Letter

Georg Thieme Verlag Stuttgart · New York

Sipandinolide: A Butenolide Including a Novel Type of Carbon Skeleton from Siparuna andina

Kristina Jenett-Siems1 , Karsten Siems2 , Jasmin Jakupovic , Pablo N. Solis3 , Mahabir P. Gupta3 , Frank P. Mockenhaupt4 , Ulrich Bienzle4 , Eckart Eich1
  • 1Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Berlin, Germany
  • 2AnalytiCon AG, Potsdam, Germany
  • 3Centro de Investigationes Farmacognosticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panama, Panama, Republica de Panama
  • 4Institut für Tropenmedizin, Medizinische Fakultät Charité der Humboldt Universität zu Berlin, Berlin, Germany
Further Information

Publication History

June 22, 1999

July 17, 1999

Publication Date:
31 December 2000 (online)

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Abstract

From a lipophilic extract of leaves of Siparuna andina (Monimiaceae), which exhibited antiplasmodial activity in vitro, two new compounds have been isolated: sipandinolide ( 1), a compound with a novel type of carbon skeleton and (-)-cis-3-acetoxy-4',5,7-trihydroxyflavanone ( 2). Their structures were established by spectroscopic methods; 2 showed moderate antiplasmodial activity whereas 1 was inactive.