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Neuropediatrics 2000; 31(1): 33-34
DOI: 10.1055/s-2000-15294
Short Communication

Georg Thieme Verlag Stuttgart · New York

Lymphocyte Inclusions in Finnish-Variant Late Infantile Neuronal Ceroid Lipofuscinosis (CLN5)

J. Rapola1 , B. D. Lake2
  • 1Department of Pathology, Haartman Institute, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland
  • 2Department of Histopathology, Great Ormond Street Hospital for Children, London, UK
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Publikationsverlauf

May 26, 1999

July 6, 1999

Publikationsdatum:
31. Dezember 2000 (online)

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Electron microscopic reinvestigation of archival samples of peripheral blood lymphocytes of four patients with Finnish-variant late infantile neuronal ceroid lipofuscinosis (CLN5) showed inclusions with dark globules and particles showing fingerprint profiles. Findings, in contrast to an earlier report, show that the lymphocytes in this disease carry pathognomonic cytosomes like all other forms of neuronal ceroid lipofuscinosis in childhood.

Key words:

NCL - CLN5 - Electron microscopy - Lymphocytes