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Synthesis 2000; 2000(1): 84-90
DOI: 10.1055/s-2000-6222
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A Facile Synthesis of Amides from 9-Fluorenylmethyl Carbamates and Acid Derivatives

Wen-Ren Li* , Hsueh-Hsuan Chou
  • *Department of Chemistry, National Central University, Chung-Li, Taiwan 32054, ROC; Fax +8 86 (3) 4 27 79 72; E-mail: WenRenLi@rs250.ncu.edu.tw
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Publication Date:
31 December 2000 (online)

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A mild and convenient one-pot procedure for the synthesis of amides from 9-fluorenylmethyl carbamates and acids using potassium fluoride, triethylamine and various coupling reagents in DMF at room temperature is described. The scope of this procedure was also tested in the coupling of a variety of 9-fluorenylmethyloxycarbonyl-protected amines with active moieties such as anhydrides, acyl imidazolides, activated esters, tosyl chlorides, and acyl halides.

9-fluorenylmethyl carbamates - peptide synthesis - potassium fluoride - BOP-Cl - amides - acids - protecting groups