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Synthesis 2000; 2000(1): 69-71
DOI: 10.1055/s-2000-6226
short paper
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A Mild and Efficient Method for the Preparation of 1,3-Dithianes from Aldehydes and Ketones

Lutz F. Tietze* , Berthold Weigand, Christian Wulff
  • *Institut für Organische Chemie, Georg-August-Universität Göttingen, Tammannstr. 2, D-37077 Göttingen, Germany; Fax +49 (5 51) 39 94 76; E-mail: ltietze@gwdg.de
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Publication Date:
31 December 2000 (online)

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A mild method for the preparation of 1,3-dithianes from aldehydes and ketones is described. By using lithium perchlorate as Lewis acid and propane-1,3-dithiol even highly acid-labile β-hydroxy aldehydes can be transformed into the corresponding thioacetals. The desired products were obtained in 41-98% yield.

1,3-dithianes - lithium perchlorate - aldehydes - ketones - Lewis acid - thiols - deprotection - sulfur