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Synthesis 2000; 2000(1): 154-164
DOI: 10.1055/s-2000-6230
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An Easy Procedure for the Preparation of 3-Methylidenetetrahydrofurans from Dimethyl Succinates

José M. Miguel del Corral* , Marina Gordaliza, M. Angeles Castro, Miguel A. Salinero, José M. Dorado, Arturo San Feliciano
  • *Departamento de Química Farmacéutica. Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain; Fax +34 (9 23) 29 45 15; E-mail: jmmcs@gugu.usal.es
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Publication Date:
31 December 2000 (online)

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A new synthetic procedure to obtain 3-methylidenetetrahydrofurans is described, in which the methylidene group is generated during the formation of the tetrahydrofuran ring. These are prepared by reduction of differently substituted dimethyl succinates obtained by Stobbe condensation

Stobbe condensation - dimethyl succinates - 2-aryl-3-methylidenetetrahydrofurans - diazomethane - reductions - heterocycles