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Synthesis 2000; 2000(4): 549-556
DOI: 10.1055/s-2000-6374
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Synthesis of Indolo[3,2-c]quinoline and Pyrido[3′,2′ : 4,5] [3,2-c]quinoline Derivatives

Abderrahim Mouaddib* , Benoît Joseph, Aissa Hasnaoui, Jean-Yves Mérour
  • *Institut de Chimie Organique et Analytique Associé au CNRS, Université d'Orléans, BP 6759, 45067 Orléans Cedex 2, France; Fax (33) 2 38 41 72 81; E-mail: jean-yves.merour@univ-orleans.fr
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Publication Date:
31 December 2000 (online)

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Potential antitumoral scaffold indolo[3,2-c]quinoline 5a was obtained by an intramolecular Heck cyclisation from the corresponding 2-iodophenyl-3-indolecarboxamide 4a. The 7-azaindole analogue 5b was prepared by the same approach. Triflate displacement of compounds 6 according to Suzuki and Stille reactions gave the 6-substituted derivatives 7-10.

indole - 7-azaindole - palladium - cyclisation - quinoline