Download PDF
Synthesis 2000; 2000(5): 731-737
DOI: 10.1055/s-2000-6403
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Convenient Dehydration Procedure for the Synthesis of Enantiomerically Pure Cyanohydrins

Fabrice Aquino* , Horst Pauling, Willy Walther, Dietmar A. Plattner, Werner Bonrath
  • *Vitamins and Fine Chemical Division, Chemical Process Technology, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland; Fax + 41(61)6 88 55 11; E-mail: Werner.Bonrath@Roche.com
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Starting from protected α-hydroxy amides, cyanohydrins (α-hydroxy nitriles) are obtained through dehydration by cyanuric chloride/DMF in excellent yield. The advantages of the procedure are the extremely mild reaction conditions that prevent racemization.

dehydration - cyanuric chloride/DMF adduct - cyanohydrins