Download PDF
Synthesis 2000; 2000(5): 703-706
DOI: 10.1055/s-2000-6404
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Convenient Synthetic Methods to C2 Symmetric 3,4-Diphenylpyrrolidines

Vutukuri Dharma Rao* , Mariappan Periasamy
  • *School of Chemistry, University of Hyderabad, Hyderabad 500 046, India; Fax + 91-040-3 01 01 20; E-mail: mpsc@uohyd.ernet.in
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Convenient methods of synthesis of racemic and optically pure 3,4-diphenylpyrrolidine derivatives, involving oxidative coupling of ethyl phenylacetate using TiCl4/Et3N and reduction of dl-2,3-diphenylsuccinic acid or the corresponding cyclic imide with NaBH4/I2 reagent in crucial steps, are described.

chiral dicarboxylic acid - diol - cyclic imide - 3,4-diphenylpyrrolidine - oxidative coupling - reductions - amines