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Synlett 2000; 2000(1): 137-139
DOI: 10.1055/s-2000-6462
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The Synthesis of N-(Pyridylamino)tetrahydroisoquinolines and Benzazepines via The Pictet-Spengler Cyclization

Gregory H. Merriman* , David M. Fink, Brian S. Freed, Barbara E. Kurys, Shelly Pavlek, Jennifer Varriano, Erich F. Paulus
  • *Medicinal Chemistry Department, Hoechst Marion Roussel Pharmaceuticals, Bridgewater, New Jersey 08807-0800; Fax (908)231-4774; E-mail: gregory.merriman@hmrag.com
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Publication Date:
31 December 2000 (online)

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A series of N-(pyridylamino)-tetrahydroisoquinolines and -benzazepines have been prepared using the Pictet-Spengler cyclization of an unprotected arylhydrazine as the key step.

Pictet-Spengler - tetrahydroisoquinolines - benzazepines - tetrazines - chloromethyl methyl ether