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Synlett 2000; 2000(2): 275-277
DOI: 10.1055/s-2000-6490
DOI: 10.1055/s-2000-6490
letter
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4-(4,6-Dimethoxy[1,3,5]triazin-2-yl)-4-methyl-morpholinium Chloride (DMTMM): A Valuable Alternative to PyBOP for Solid Phase Peptide Synthesis
Further Information
Publication History
Publication Date:
31 December 2000 (online)
The salt formed from 2-chloro-4,6-dimethoxy[1,3,5]triazine and N-methylmorpholine (DMTMM) is an effective coupling agent for solid phase peptide synthesis that can be used as economical alternative to PyBOP. Several oligopeptides were prepared on a Wang type resin using this reagent and the yields and purity of the products were always comparable with those obtained with PyBOP as the coupling agent.
coupling reagents - solid phase synthesis - peptides - triazines