Download PDF
Synlett 2000; 2000(4): 532-534
DOI: 10.1055/s-2000-6557
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Carbolithiation of an α-Amino Lithio Alkoxide Derived from Cinnamaldehyde

Nathalie Brémand* , Jean F. Normant, Pierre Mangeney
  • *Laboratoire de Chimie des Organoéléments, Université Pierre et Marie Curie, 4, Place Jussieu, Tour 44-45, 2e étage, Boite 183, 75252 Paris cedex 05, France; Fax 33 (1) 44 27 75 67; E-mail: normant@ccr.jussieu.fr
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Cinnamaldehyde adds alkyllithiums on the carbon carbon double bond regioselectively, after protection by the amide of N,N,N′ trimethylethanediamine. The benzyllithium reagent thus obtained reacts with electrophiles diastereoselectively.

aldehyde - nucleophilic addition - amination - carbolithiation - diastereoselection