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Synlett 2000; 2000(5): 0698-0700
DOI: 10.1055/s-2000-6615
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Synthesis of N-Alkyl-(α-Aminoalkyl)Phosphine Oxides and Phosphonic Esters as Potential HIV-Protease Inhibitors, Starting from α-Aminoacids

Edgar Alonso* , Eduardo Alonso, Ana Solís, Carlos del Pozo
  • *Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, 33071 Oviedo, Spain; Fax (34) 98 510 34 50; E-mail: FJGF@sauron.quimica.uniovi.es
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Publication Date:
31 December 2000 (online)

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The synthesis of α-aminophosphonic acid derivatives starting from α-aminoacids is described. These phosphorus peptide mimics could be potential HIV-protease inhibitors.

α-aminophosphonic acids - α-aminoacids - peptide mimics - HIV-protease inhibitors - azomethine asymmetric addition