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Synlett 2000; 2000(5): 0591-0594
DOI: 10.1055/s-2000-6638
DOI: 10.1055/s-2000-6638
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Soluble Polymer-Supported Synthesis of a Benzimidazole Library
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Publication History
Publication Date:
31 December 2000 (online)
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The synthesis of benzimidazole 1 using a liquid phase approach is described. Aromatic substitution of immobilized o-fluoronitrobenzene 2 with various amines to o-nitroaniline derivatives 3 is carried out in methylene chloride. Reduction of the aromatic nitro group, followed by subsequent cyclization/elimination gives the benzimidazole skeleton. The crude library members obtained are of high yields and chemical purities after cleavage.
benzimidazole - combinatorial chemistry - liquid-phase method - solid-phase method - scaffold