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Synlett 2000; 2000(5): 0591-0594
DOI: 10.1055/s-2000-6638
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Soluble Polymer-Supported Synthesis of a Benzimidazole Library

Yu-Chung Chi* , Chung-Ming Sun
  • *Department of Chemistry, National Dong Hwa University, Shou-Feng, Hualien 974, Taiwan; Fax (886)-3-8661487; E-mail: cmsun@mail.ndhu.edu.tw
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Publication Date:
31 December 2000 (online)

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The synthesis of benzimidazole 1 using a liquid phase approach is described. Aromatic substitution of immobilized o-fluoronitrobenzene 2 with various amines to o-nitroaniline derivatives 3 is carried out in methylene chloride. Reduction of the aromatic nitro group, followed by subsequent cyclization/elimination gives the benzimidazole skeleton. The crude library members obtained are of high yields and chemical purities after cleavage.

benzimidazole - combinatorial chemistry - liquid-phase method - solid-phase method - scaffold