Download PDF
Synlett 2000; 2000(5): 0671-0673
DOI: 10.1055/s-2000-6640
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Chlorination of Nucleosides by N-chlorodiisopropylamine and Triphenylphosphine

Yi-Sui Zhou* , Z.-W. Miao, Yu-Fen Zhao
  • *Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, School of life science and Engineering, Tsinghua University, Beijing, 100084, P.R. China; Fax 010-62781695; E-mail: tp-dch@mail.tsinghua.edu.cn
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The combination of N-chlorodiisopropylamine and triphenylphosphine (1) was exploited as a new method for chlorination of the hydroxyl group on the nucleosides. A possible mechanism involving an oxyphosphonium intermediate 2a and a phosphorane intermediate 2b was proposed based on the results from 31P NMR spectrum.

chlorination - NMR - nucleosides