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Synlett 2000; 2000(7): 1019-1021
DOI: 10.1055/s-2000-6672
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The First Synthesis of (+)-Tanikolide, a Toxic and Antifungal Lactone from the Marine Cyanobacterium Lyngbya majuscula

Regina Mikie Kanada* , Takahiko Taniguchi, Kunio Ogasawara
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan; Fax + 81-22-217-6845; E-mail: konol@mail.cc.tohoku.ac.jp
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Publication Date:
31 December 2000 (online)

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(+)-Tanikolide, a toxic and antifungal lactone isolated from the marine cyanobacterium Lyngbya majuscula, has been synthesized enantioselectively by employing a catalytic asymmetric hydrogen transfer reaction as the key step. The synthesis has confirmed the validity of the proposed structure concluded on the basis of spectroscopic data.

tanikolide - asymmetric hydrogen transfer - structure determination - chiral building block - marine natural product