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Synlett 2000; 2000(6): 0815-0816
DOI: 10.1055/s-2000-6715
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Facile "One-Pot" Preparation of Phosphonothiolformates. Useful Reagents for the Synthesis of Carbamoylphosphonates

Claudio J. Salomon* , Eli Breuer
  • *Department of Medicinal Chemistry, School of Pharmacy, The Hebrew University of Jerusalem, POB 12065, Jerusalem, Israel; E-mail: salomon@citynet.net.ar; breuer@cc.huji.ac.il
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Publication Date:
31 December 2000 (online)

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A versatile and mild "one-pot" reaction for the preparation of trialkyl phosphonothiolformates was accomplished by sequential reaction of phosgene solution with alkanethiols, and subsequent Arbuzov reaction with trialkyl phosphites.

phosphonic acids - phosphonothiolformates - carbamoylphosphonates - one pot reaction - Arbuzov reaction