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Synlett 2000; 2000(6): 0829-0831
DOI: 10.1055/s-2000-6718
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A Convenient Synthesis of Heteroaryl Benzoic Acids via Suzuki Reaction

Yong Gong* , Henry W. Pauls
  • *Department of Medicinal Chemistry, Rhone-Poulenc Rorer, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA; Fax 610 454 3311; E-mail: yong.gong@aventis.com
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Publication Date:
31 December 2000 (online)

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An one step approach to heteroaryl benzoic acids from readily accessible heteroaryl halides and carboxybenzene boronic acids is described. The Suzuki coupling is carried out in the presence of Pd(PPh3)4 and sodium carbonate in aqueous acetonitrile. The scope and limitations of the reaction are discussed.

biaryls - carboxylic acids - cross-coupling - heteroaryl halides - palladium