Download PDF
Synlett 2000; 2000(6): 0809-0810
DOI: 10.1055/s-2000-6727
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Selective N-Methylation of Pyrazolone with Methanol by Use of ZrO2 Catalyst in the Liquid Phase

Sumio Shinoda* , Satoru Shima, Tetsu Yamakawa
  • *Institute of Industrial Science, The University of Tokyo, 7-22-1 Roppongi, Minato-ku, Tokyo 106-8558, Japan; Fax +81-03-3402-6350; E-mail: yamakawa@iis.u-tokyo-ac.jp
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Selective methylation of pyrazolone to 1-methylpyrazolone was investigated with ZrO2, which is a representative metal oxide with amphoteric character. The high selectivity up to ∼ 77% was obtained at 503 K. Mechanism is proposed in view of weak acidic-moderately basic pair sites of ZrO2.

pyrazolone - selective methylation - methanol - metal oxide catalyst