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Semin Musculoskelet Radiol 2000; Volume 4(Number 1): 0137-0146
DOI: 10.1055/s-2000-6861
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel: +1(212)584-4662

Imaging Evaluation of the Response of High-Grade Osteosarcoma and Ewing Sarcoma to Chemotherapy with Emphasis on Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Lorraine G. Shapeero, Daniel Vanel
  • Department of Radiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland and Department of Radiology, Walter Reed Army Medical Center, Washington, DC (LGS); and Department of Radiology, Institut Gustave Roussy, Villejuif, France (DV)
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Publication Date:
31 December 2000 (online)

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ABSTRACT

-Response of high-grade osteosarcoma and Ewing sarcoma to preoperative chemotherapy can significantly affect the surgical approach to patients with these tumors and their disease-free survival. This article presents the findings and limitations of different imaging modalities (radiography, angiography, sonography, scintigraphy, and magnetic resonance [MR] imaging and spectroscopy) for evaluating this chemotherapeutic response. Particular emphasis is given to the currently most effective modality-dynamic contrast-enhanced MR imaging.

KEYWORD

Bone, neoplasms - osteosarcoma - chemotherapy - Ewing sarcoma - magnetic resonance (MR) - rapid imaging