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Synthesis 2000; 2000(10): 1369-1371
DOI: 10.1055/s-2000-7110
short paper
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Synthesis of Monosubstituted Succinic Acids from tert-Butylsuccinate

Stephen C. Bergmeier* , Khadiga A. Ismail
  • *Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 W.12th Ave, Columbus, OH 43210-1291, USA; Fax 74 05 93 10 48; E-mail: Bergmeis@ohio.edu
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Publication Date:
31 December 2000 (online)

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We report the preparation and alkylation of the dianion of t-butylsuccinate. This alkylation reaction has proven to be a useful method for the preparation of monosubstituted succinic acids and anhydrides.

alkylations - carboxylic acids - esters - dianions