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Synlett 2000; 2000(9): 1327-1329
DOI: 10.1055/s-2000-7131
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Cyclocondensation of β-Enaminonitriles, Carbonyl Compounds and Acetonitrile. An Effective Route to Various Six-Membered Lactams

Péter Nemes* , Barbara Balázs, Gábor Tóth, Pál Scheiber
  • *Department of Chemistry, Faculty of Veterinary Science, Szent István University, H-1400 Budapest, P.O. Box 2, Hungary
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Publication Date:
31 December 2000 (online)

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A cyclocondensation of β-enaminonitriles, carbonyl compounds and acetonitrile is described. Using different cyclic or open chain enaminonitriles various N-heterocycles were obtained in a one-step procedure. The base catalysed reaction was also carried out with α,β-unsaturated nitriles under similar conditions.

β-enaminonitriles - α,β-unsaturated nitriles - cyclocondensation - polycyclic lactams - alkaloid analogues