Synlett 2000; 2000(9): 1275-1276
DOI: 10.1055/s-2000-7141
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A Mild and Selective Cleavage of Tritylethers by Cerium(III) Chloride

J. S. Yadav* , B. V. Subba Reddy
  • *Organic Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India; E-mail: yadav@iict.ap.nic.in
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Publication History

Publication Date:
31 December 2000 (online)

Trityl ethers are selectively cleaved by cerium(III) chloride in high yields in refluxing acetonitrile under neutral reaction conditions. The method is compatible with other acid sensitive functional groups like acetonide, acetate, benzoate, BOC, Cbz, benzyl, TBDPS, PMB, allyl, methyl and tetrahydropyranyl ethers present in the molecule.