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DOI: 10.1055/s-2000-7496
Georg Thieme Verlag Stuttgart · New York
MR Patterns of Hypoxic-Ischemic Brain Damage After Prenatal, Perinatal or Postnatal Asphyxia[*]
Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
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The relationship between MR patterns of brain damage and type or timing of perinatal hypoxia-ischemia was studied. MR images of 104 children with evidence of bilateral posthypoxic-ischemic brain damage and neonatal records were reviewed. Three different MR patterns were found. Periventricular leukomalacia occurred in 73 children, in 82 % after a history of subacute or chronic hypoxia-ischemia, in 71 % after preterm birth. Predominant lesions of basal ganglia and thalamus occurred in 21 children, in 95 % preceded by acute profound asphyxia, in 85 % after term birth. Multicystic encephalopathy occurred in 10 infants, in 70 % preceded by mild signs of hypoxia-ischemia, followed by an unexpectedly severe encephalopathy, in 60 % after term birth. Statistical analysis showed that the patterns of injury were primarily related to the type of hypoxia-ischemia. We conclude that the type of hypoxia-ischemia, rather than the postconceptional age at occurrence determines the pattern of brain injury.
Key words
Children - MR - Brain - Central nervous system - Asphyxia
1 Parts of this study have been presented at the “European Paediatric Neurology Society”, October 1997, Maastricht, The Netherlands.
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1 Parts of this study have been presented at the “European Paediatric Neurology Society”, October 1997, Maastricht, The Netherlands.
Prof. Dr. M. S. van der Knaap
Department of Child Neurology Free University Hospital
De Boelelaan 1117
1081 HV Amsterdam
The Netherlands
eMail: E-mail: ms.vanderknaap@azvu.nl