Tetrabutylammoninm Peroxydisulfate in Organic Synthesis X. An Efficient Nickel-Catalyzed One-Pot Synthesis of Nitriles from Aldehydes by Oxidation with Tetrabutylammonium Peroxydisulfate

Fen-Er Chen; Han Fu; Ge Meng; Yu Cheng; Yin-Xiang Lü

doi:10.1055/s-2000-7595

Synthesis 2000; 2000(11): 1519-1520
DOI: 10.1055/s-2000-7595

short paper

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Tetrabutylammoninm Peroxydisulfate in Organic Synthesis X. An Efficient Nickel-Catalyzed One-Pot Synthesis of Nitriles from Aldehydes by Oxidation with Tetrabutylammonium Peroxydisulfate

Fen-Er Chen^* , Han Fu, Ge Meng, Yu Cheng, Yin-Xiang Lü

^*Department of Chemistry, Fudan University, Shanghai 200433, People's Republic of China; Fax + 86 (21) 65 65 20 21; E-mail: rfchen@fudan.edu.cn

Abstract

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Various aliphatic, aromatic and heterocyclic aldehydes were efficiently transformed to the corresponding nitriles in a one-pot procedure by nickel-catalyzed oxidation with tetrabutylammonium peroxydisulfate in the presence of ammonium hydrogen carbonate under basic aqueous conditions. The process affords excellent yields of pure nitriles.

tetrabutylammonium peroxydisulfate - aldehydes - nitriles - oxidations

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