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Synthesis 2000; 2000(11): 1579-1584
DOI: 10.1055/s-2000-7615
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An Efficient Synthesis of N-Protected β-Aminoethanesulfonyl Chlorides: Versatile Building Blocks for the Synthesis of Oligopeptidosulfonamides

Arwin J. Brouwer* , Menno C. F. Monnee, Rob M. J. Liskamp
  • *Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands; Fax (+ 31) 3 02 53 66 55; E-mail: R.M.J.Liskamp@pharm.uu.nl
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Publication Date:
31 December 2000 (online)

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A very efficient method for the synthesis of β-aminoethanesulfonyl chlorides is described. These aliphatic functionalized sulfonyl chlorides are accessible starting from a variety of protected amino acids, including those having functionalized side chains.

sulfonamides - sulfonyl chloride - amino acid - thioacetate - oxidation