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Synlett 2000; 2000(10): 1488-1490
DOI: 10.1055/s-2000-7644
DOI: 10.1055/s-2000-7644
letter
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Facile Cyanomethylation of Bromopyridines by Nucleophilic Substitution with Lithioacetonitrile
Further Information
Publication History
Publication Date:
31 December 2000 (online)
Substituted bromopyridines undergo facile nucleophilic substitution with lithioacetonitrile under mild conditions to afford the corresponding cyanomethylated products.
cyanomethylation - bromopyridines - halopyridines - aromatic nucleophilic substitution - lithioacetonitrile