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Endoscopy 2000; 32(10): 783-787
DOI: 10.1055/s-2000-7707
Original Article
© Georg Thieme Verlag Stuttgart · New York

Diagnostic Quality in Endoscopic Retrograde Cholangiopancreatography: Comparison Between Iodixanol and Iopromide

D. F. Martin 1 , R. E. England 1 , T. Rösch 2 , E. Biehl 2 , B. Jeschke 2 , N. Fritz 2 , D. Heldwein 3 , A. Klauser 3 , A. Klaveness 4 , D. Kristoffersen 4
  • 1 Dept. of Radiology, South Manchester University Hospitals, Withington Hospital, Manchester, UK
  • 2 Dept. of Internal Medicine II, Technical University of Munich, Munich, Germany
  • 3 MCHE Klinik, K Innenstadt, Ludwig-Maximilians University, Munich, Germany
  • 4 Nycomed Imaging AS, Oslo, Norway
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Publikationsdatum:
31. Dezember 2000 (online)

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Background and Study Aims: The contrast medium for endoscopic retrograde cholangiopancreatography (ERCP) must produce adequate images, whilst keeping the risk of complications to a minimum. There is a theoretical reason to suppose that a dimeric isosmolar medium may be superior to a monomeric hyperosmolar medium. We have compared two such media in a triple-centre double-blind randomized study on patients referred with a clinical indication for ERCP.

Patients and Methods: A total of 160 patients were randomly allocated to either Iodixanol or Iopromide. Assessments were made of the quality of images and the complications encountered.

Results: A total of 151 patients were evaluated. Apart from a trend towards better diagnostic quality for main pancreatic duct imaging with Iodixanol, there were no differences between the two groups. The overall frequencies of adverse events were similar.

Conclusions: Iodixanol is a safe and effective water-soluble contrast medium for ERCP, comparable to Iopromide, but despite theoretical advantages Iodixanol has no clear practical benefit.

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D. F.  Martin,M.D., F.R.C.R., F.R.C.P. 

Dept. of Radiology South Manchester University Hospitals Withington Hospital

Manchester M20 2LR United Kingdom

Fax: Fax:+ 44-161-4481688

eMail: E-mail:derrickmartin@hotmail.com