Thorac Cardiovasc Surg 2000; 48(5): 311-315
DOI: 10.1055/s-2000-7874
Review
© Georg Thieme Verlag Stuttgart · New York

Diagnosis, Treatment and Outcome of Patients with Askin-Tumors

S. Christiansen1 , M. Semik1 , B. Dockhorn-Dworniczak2 , J. Rötker1 , M. Thomas3 , C. Schmidt4 , H. Jürgens5 , W. Winkelmann6 , H. H. Scheld1
  • 1Klinik und Poliklinik für Thorax-, Herz- und Gefäßchirurgie
  • 2Gerhard-Domagk-Institut für Pathologie
  • 3Klinik und Poliklinik für Hämatologie/Onkologie
  • 4Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin
  • 5Klinik und Poliklinik für Pädiatrische Hämatologie/Onkologie
  • 6Klinik und Poliklinik für Orthopädie
  • Westfälische Wilhelms-Universität Münster, Germany
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Askin tumors are highly malignant small-round-cell tumors of the thoracopulmonary region, which occur rarely. Therefore, we report on our experiences with eight patients (5 male, 3 females), who were treated in our department between 11'94 and 10'97 (age: 9 - 40 years, mean age: 20.5 years). All Askin tumors were diagnosed by histological and immunohistochemical examinations as well as moleculargenetic proof of characteristic translocations. In all patients, the tumor arose from the chest wall, infiltrating adjacent ribs and parts of the lung. At the time of first diagnosis, five patients did not reveal any metastases. One patient suffered from intrapulmonary metastases and two patients from an infiltration of the diaphragm and of adjacent vertebral bodies. Treatment consisted of a pre- and postoperative (radio-) chemotherapy according to the EVAIA protocol and a radical tumor resection in all patients. The postoperative course was uneventful in seven patients, one patient suffered from pneumonia after multiple wedge resections for intrapulmonary metastases. Four patients, in whom primary tumor resection was complete, are alive 14, 20, 35 and 84 months after first diagnosis - only one patient had to undergo a second operation for a local relapse 17 months after first diagnosis. The other 4 patients, who suffered from a very extensive primary tumor, expired 13, 17, 18 and 39 months after the diagnosis was made. Our data demonstrate that Askin tumors require an aggressive multimodality treatment consisting of pre- and postoperative chemotherapy, radical surgical resection and postoperative irradiation, which may be performed preoperatively in selected cases, too.

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Dr. med. S. Christiansen

Klinik und Poliklinik für Thorax-, Herz- und Gefäßchirurgie Westfälische Wilhelms-Universität Münster

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48149 Münster

Germany

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