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Synlett 2000; 2000(11): 1661-1663
DOI: 10.1055/s-2000-7930
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Towards Pateamine. A Comparison of Palladium-catalysed sp2-sp2 Coupling Protocols to Polyene Macrolides

Christine Câline* , Gerald Pattenden
  • *School of Chemistry, The University of Nottingham, Nottingham NG7 2RD, England; Fax +44 1 15 9 51 35 35; E-mail: gp@Nottingham.ac.uk
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Publication Date:
31 December 2000 (online)

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The Heck reaction is compared with the Stille reaction in the elaboration of the Z-2,E-4 diene acrylate unit in the model compounds 2a and 2b as an approach to the polyene macrolide core of the immunosuppressant agent pateamine 1 produced by the marine sponge Mycale sp.

Heck - Stille - macrolides - pateamine - supercritical solvents