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Synthesis 2000; 2000(13): 1907-1916
DOI: 10.1055/s-2000-8225
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Synthesis of Drimanes from (+)-Larixol

Béatrice M. F. Lagnel* , Christophe Morin, Aede de Groot
  • *Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB Wageningen, The Netherlands
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Publication Date:
31 December 2000 (online)

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The selective transformation of the side chain of larixol 1 to a functionalized one-carbon moiety leads to 6,8-diacetoxydrimenal 13, which was converted to the drimanes (-)-albrassitriol (2), (-)-drimenol (3), (-)-uvidin C (4) and (-)-epi-albrassitriol (5).

drimane sesquiterpenoids - natural product synthesis - (+)-larixol - (-)-albrassitriol - (-)-uvidin C - (-)-epi-albrassitriol