Download PDF
Planta Med 2000; 66(4): 358-360
DOI: 10.1055/s-2000-8531
Letter
Georg Thieme Verlag Stuttgart · New York

Anti-Allergic and Anti-Inflammatory Triterpenes from the Herb of Prunella vulgaris

Shi Yong Ryu1 , Min-Ho Oak2 , Seok-Keun Yoon1 , Dong-Im Cho2 , Gyurng-Soo Yoo2 , Tae-Sung Kim2 , Kyeong-Man Kim2,*
  • 1 Korea Research Institute of Chemical Technology, Yusung, Taejeon, Korea
  • 2 Pharmacology Laboratory, College of Pharmacy, Drug Development Research Center, Chonnam National University, Kwang-Ju, Korea
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Also available at
    Permissions and Reprints

Abstract

The activity-guided fractionation of the extract of the herb of Prunella vulgaris (Labiatae) led to the isolation of four triterpenes, i.e., betulinic acid, ursolic acid, 2α,3α-dihydroxyurs-12-en-28-oic acid, and 2α-hydroxyursolic acid. One of these compounds, 2α,3α-dihydroxyursolic acid, demonstrated significant inhibition on the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner; the IC50 value was calculated to be 57 μM. When the isolated compounds were tested for their effects on the production of nitric oxide from cultured murine macrophages, RAW 264.7 cells, ursolic acid and 2α-hydroxyursolic acid exhibited strong inhibitory activities (IC50 values, 17 and 27μM, respectively).

References

  • 1 Choi  S H,, Kim  Y R,, Lim  D K,, Bae  E O.. Studies of anti-allergic actions of several natural products - I.  Yakhak Hoiji. 1992;;  36 140-9
    PubMedSearch in Google Scholar
  • 2 Choi  S H,, Bae  E O,, Lim  D K,, Kim  Y R.. Studies of anti-allergic actions of several natural products -II.   Yakhak Hoiji. 1992;;  36 357-69
    PubMedSearch in Google Scholar
  • 3 Cheong  H,, Choi  E J,, Yoo  G S,, Kim  K M,, Ryu  S Y.. Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum. .  Planta Med.. 1998;;  64 577-8
    PubMedSearch in Google Scholar
  • 4 Tsuruga  T,, Chun  Y,, Ebizuka  Y,, Sankawa  U.. Biologically active constituents of Melaleuca leucadendron: Inhibitors of induced histamine release from rat mast cells.  Chem. Pharm. Bull.. 1991;;  39 3276-78
    PubMedSearch in Google Scholar
  • 5 Manez  S,, Recio  M C,, Giner  R M,, Rios  J L.. Effect of selected triterpenoids on chronic dermal inflammation.  Eur. J. Pharmacol.. 1997;;  334 103-5
    CrossrefPubMedSearch in Google Scholar
  • 6 Ohshima  H,, Bartsch  H.. Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis.  Mutat. Res.. 1994;;  305 253-64
    PubMedSearch in Google Scholar
  • 7 Ryu  S Y,, Lee  C K,, Lee  C O,, Kim  H S,, Zee  O P.. Antiviral triterpenes from Prunella vulgaris.   Arch. Pharm. Res.. 1992;;  15 242-5
    PubMedSearch in Google Scholar
  • 8 Walker  G,, Pfeilschifter  J,, Kunz  D.. Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in interferon (IFN)-gamma-stimulated RAW 264.7 cells by dexamethasone. Evidence for glucocorticoid-induced degradation of iNOS protein by calpain as a key step in posttranscriptional regulation.  J. Biol. Chem.. 1997;;  272 16679-87
    PubMedSearch in Google Scholar

D Ph. Kyeong-Man Kim

Pharmacology Laboratory College of Pharmacy Chonnam National University

Kwang-Ju 500-757

Korea

Email: kmkim@chonnam.chonnam.ac.kr

Phone: +82-62-530-2949