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Planta Med 2000; 66(4): 337-342
DOI: 10.1055/s-2000-8534
Original Paper
Georg Thieme Verlag Stuttgart · New York

Assessment of Antimycobacterial Activity of a Series of Mainly Marine Derived Natural Products

Gabriele M. König1,*, Anthony D. Wright1 , Scott G. Franzblau2
  • 1 Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany
  • 2 GWL Hansen's Disease Center, Baton Rouge, Louisiana, USA
Further Information

Publication History

Publication Date:
31 December 2000 (online)

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Abstract

A series of mainly marine derived natural products were tested for their activities against Mycobacterium tuberculosis and M. avium. Of the thirty-nine compounds tested fifteen demonstrated minimum inhibition concentrations (MICs) of 32 μg/ml or less, and eleven had MICs of 16 μg/ml or less. The most active compound found in this study was the sponge derived metabolite axisonitrile-3 (MIC 2 μg/ml).

Key words

Marine natural products - Mycobacterium tuberculosis - Mycobacterium avium - biological testing - tuberculosis

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Prof. G. M. König

Institute for Pharmaceutical Biology University of Bonn

Nußallee 6

53115 Bonn

Germany

Email: g.koenig@uni-bonn.de

Phone: +49 (0) 228 733 250

URL: http://www.tu-bs.de/institute/pharm.biol/GAWK.html