Subscribe to RSS
DOI: 10.1055/s-2000-8544
A New Acylated Flavonol Glycoside and Antioxidant Effects of Hedyotis diffusa
Publication History
Publication Date:
31 December 2000 (online)

Abstract
A study on the bioactive principles of Hedyotis diffusa Willd., led to the isolation of a new acyl flavonol di-glycoside which was characterized as kaempferol 3-O[2″-O-(E-6′′′-O-feruloyl)-β-D-glucopyranosyl]-β-D-galactopyranoside by spectral and chemical methods from the methanolic extract. In addition, three known flavonol glycosides and six known iridoid glycosides were also obtained. The above-mentioned glycosides were tested for antioxidant effects on xanthine oxidase inhibition, xanthine-xanthine oxidase cytochrome c and TBA-MDA systems.
References
-
1 Kan W S..
10.15 Rubiaceae, 10. Angiospermae. The Chinese Medicine Publishing Inc. Pharmaceutical Botany, Taipei, Taiwan, R.O.C.; 1986: 522 - 2 Yang J J,, Hsu H Y,, Lin C C.. The possible use of Peh-Hue-Juwa-Chi-Cao as an antitumor agent and radioprotector after therapeutic irradiation. Phytotherapy Research. 1997;; 11 6-10
- 3 Bojthe-Horvath K,, Hetenyi F,, Kocsis A,, Szabo L,, Varga-Balaz M,, Mathe Jr I et al.. Iridoid glycosides from Galium verum. . Phytochemistry. 1982;; 21 2917-9
- 4 Takagi S,, Yamaki M,, Nishihama Y,, Ishiguro K.. On the iridoid glycosides of the Chinese drug “bai hua she she cao” (Hedyotis diffusa Willd.). Shyoyakugaku Zasshi. 1982;; 36 366-9
- 5 Nishihama Y,, Masuda K,, Yamaki M,, Takagi S,, Sakina K.. Three new iridoid glycosides from Hedyotis diffusa. Planta Medica. 1981;; 43 28-33
- 6 Huang J T.. New iridoids from Oldenlandia diffusa Roxb. Arch. Pharm.. 1981;; 314 831-6
- 7 Halliwell B.. Reactive oxygen species in living systems: source, biochemistry and role in human disease. Am. J. Med.. 1991;; 91 14-22S
-
8 Harborne J B,, Mabry T J,, Mabry H..
2.1 Ultraviolet and visible absorption spectroscopy, 2. Ultraviolet-visible and proton magnetic resonance spectroscopy of flavonoids. part In: The Flavonoids,. Markham KR, Mabry TJ, editors Chapman and Hall 1975: 48 - 60; - 9 Murakami T,, Wada H,, Stanley R,, Tanaka N,, Kido T,, Iida H et al.. Chemical and chemotaxonomical studies of filices. LXV. A few new flavonol glycosides. Yakugaku Zasshi. 1986;; 106 982-8
- 10 Agrawal P K,, Rastogi R P.. 13C NMR spectroscopy of flavonoids. Heterocycles. 1981;; 16 2181-236
- 11 Agrawal P K.. NMR spectroscopy in the structural elucidation of oligosaccarides and glycosides. Phytochemistry. 1992;; 10 3307-30
- 12 Lin C C,, Chen J Y,, Namba T.. Development of natural crude drug resources from Taiwan (V). Pharmaceutical studies on Chinese crude drug “Peh-hue-juwa-chi-chhau“. Shyoyakugaku Zasshi. 1987;; 41 180-8
- 13 Markham K R,, Ternai B,, Stanley R,, Geiger H,, Mabry T J.. Carbon-13 NMR studies of flavonoids - III Naturally occurring flavonoid glycosides and their acylated derivatives. Tetrahedron. 1978;; 34 1389-97
- 14 Chang W S,, Chang Y H,, Lu F J,, Chiang H C.. Inhibitory effects of phenolics on xanthine oxidase. 1994;; 14 501-6
- 15 Mc Cord J M,, Fridovich I.. An enzymatic function for erythro-cuprein (Hemocuprein). J. Biol. Chem.. 1969;; 244 6049-58
- 16 Yoden K,, Iio T,, Tabata T.. Measurement of thiobarbituric acid value in tissue homogenate solubilized with sodium dodecyl sulphate. Yakugaku Zasshi. 1980;; 100 553-9
- 17 Kimuya K,, Kubo M,, Tani T,, Arich S,, Okuda H.. Studies on Scutellariae Radix. IV. Effects on lipid peroxidation in rat liver homogenate. Chem. Pharm. Bull.. 1981;; 29 2610-7
Prof. Dr. C. C. Lin
College of Pharmacy Kaohsiung Medical University
Kaohsiung
Taiwan 807 R.O.C.
Email: aalin@ms24.hinet.net
Phone: +886 7 3227508