Planta Med 2000; 66(4): 377-379
DOI: 10.1055/s-2000-8550
Letter
Georg Thieme Verlag Stuttgart · New York

Evaluation of the Antiviral Activity of Kaempferol and its Glycosides Against Human Cytomegalovirus

Dimitra Mitrocotsa1 , Sofia Mitaku1,*, Stavros Axarlis2 , Catherine Harvala1 , Michalis Malamas3
  • 1 Division of Pharmacognosy, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens, Greece
  • 2 Hellenic Pasteur Institute, Athens, Greece
  • 3 Department of Pharmacology, Medical School, University of Ioannina, Ioannina, Greece
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

Abstract

The antiviral activity of seven flavonoids, belonging to the kaempferol series, was evaluated against human cytomegalovirus (HCMV) by a rapid method of detection of the immediate-early (IE) antigen, induced by the virus in infected cells. Flavonoids bearing acyl substituents were found to be the most active compounds.

References

  • 1 Alford  C A,, Britt  W J.. Cytomegalovirus. Virology 2nd edn. Knipe DM, Fields BN, editors New York:; Raven Press, 1990: 1891-2010
  • 2 Sinzger  C,, Jahn  G.. Human cytomegalovirus cell tropism and pathogenesis.  Intervirology. 1996;;  39 302-19
  • 3 Faulds  D,, Heel  R C.. Ganciclovir: A review of its antiviral activity, pharmacokinetic properties and the efficacy in cytomegalovirus infections.  Drugs. 1990;;  39 597-638
  • 4 Pathak  D,, Pathak  K,, Singla  A K.. Flavonoids as medicinal agents - Recent advances.  Fitoterapia. 1991;;  62 371-89
  • 5 Mori  A,, Nishino  C,, Enoki  N,, Tawata  S.. Antibacterial activity and mode of action of plant flavonoids against Proteus vulgaris and Staphylococcus aureus. .  Phytochemistry. 1987;;  26 2231-4
  • 6 Ubeda  A,, Esteve  M L,, Alkaraz  M J,, Cheeseman  K H,, Slater  T F.. Effects of flavonoids on cytochrome P-450 rat liver microsomes: Inhibition of enzyme activities and protection against peroxidative damage.  Phytotherapy Research. 1995;;  9 416-20
  • 7 Panthong  A,, Kanjanapothi  D,, Tuntiwachwuttikul  P,, Pancharoen  O,, Reutrakul  V.. Anti-inflammatory activity of flavonoids.  Phytomedicine. 1994;;  1 141-4
  • 8 Akiyama  T,, Ishida  J,, Nakagama  S,, Ogawara  H,, Watanabe  I,, Itoh  N et al.. Genistein, a specific inhibitor of tyrosine-specific protein kinases.  Journal of Biological Chemistry. 1987;;  262 5592-5
  • 9 Bidel  C G,, Poirson  J.. Composition for the treatment or prevention of herpes.  WO. 1995:;  95/09635
  • 10 Vlietinck  A J,, De Bruyne  T,, Apers  S,, Pieters  L A.. Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection.  Planta Medica. 1998;;  64 97-109
  • 11 Lin  Y M,, Flavin  M T,, Schure  R,, Chen  F C,, Sidwell  R,, Barnard  D L et al.. Antiviral activities of biflavonoids.  Planta Medica. 1999;;  65 120-5
  • 12 Barnard  D L,, Smee  D F,, Huffman  J H,, Meyerson  L R,, Sidwell  R W.. Antiherpesvirus activity and mode of action of Sp-303, a novel plant flavonoid.  Chemotherapy. 1993;;  39 203-11
  • 13 Hudson  J B.. Antiviral compounds from plants. CRC Press,. Boca Raton:; 1990
  • 14 Hayashi  K,, Hayashi  T,, Otsuka  H,, Takeda  Y.. Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the anitherpes acyclovir.  Journal of Antimicrobial Chemotherapy. 1997;;  39 821-4
  • 15 Mitrocotsa  D,, Mitaku  S,, Demetzos  C,, Harvala  C,, Mentis  A,, Perez  S et al.. Bioactive compounds from the buds of Platanus orientalis and isolation of a new kaempferol glycoside.  Planta Medica. 1993;;  59 517-20
  • 16 Alpert  G,, Mazeron  M C,, Colimon  R,, Plotkin  S.. Rapid detection of human cytomegalovirus in the urine of humans.  Journal of Infectious Diseases. 1985;;  152 631-3
  • 17 Mazeron  M C,, Jahn  G,, Platcher  B.. Monoclonal antibody E-13 (M-810) to human cytomegalovirus recognizes an epitope encoded by exon 2 of the major immediate early gene.  Journal of general Virology. 1992;;  3 2699-703
  • 18 Axarlis  S,, Mentis  A,, Demetzos  C,, Mitaku  S,, Skaltsounis  A L,, Marselos  M et al.. Antiviral in vitro activity of Hypericum perforatum L. extract on the human cytomegalovirus (HCMV).  Phytotherapy Research. 1998;;  12 507-11

Pr. S. Mitaku

Division of Pharmacognosy School of Pharmacy University of Athens

Panepistimiopolis Zografou

Athens 15771

Greece

eMail: mitakou@pharm.uoa.gr

Telefon: 017274594