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Planta Med 2000; 66(4): 377-379
DOI: 10.1055/s-2000-8550
DOI: 10.1055/s-2000-8550
Letter
Georg Thieme Verlag Stuttgart · New York
Evaluation of the Antiviral Activity of Kaempferol and its Glycosides Against Human Cytomegalovirus
Further Information
Publication History
Publication Date:
31 December 2000 (online)
Abstract
The antiviral activity of seven flavonoids, belonging to the kaempferol series, was evaluated against human cytomegalovirus (HCMV) by a rapid method of detection of the immediate-early (IE) antigen, induced by the virus in infected cells. Flavonoids bearing acyl substituents were found to be the most active compounds.
References
-
1 Alford C A,, Britt W J..
Cytomegalovirus. Virology 2nd edn. Knipe DM, Fields BN, editors New York:; Raven Press, 1990: 1891-2010 - 2 Sinzger C,, Jahn G.. Human cytomegalovirus cell tropism and pathogenesis. Intervirology. 1996;; 39 302-19
- 3 Faulds D,, Heel R C.. Ganciclovir: A review of its antiviral activity, pharmacokinetic properties and the efficacy in cytomegalovirus infections. Drugs. 1990;; 39 597-638
- 4 Pathak D,, Pathak K,, Singla A K.. Flavonoids as medicinal agents - Recent advances. Fitoterapia. 1991;; 62 371-89
- 5 Mori A,, Nishino C,, Enoki N,, Tawata S.. Antibacterial activity and mode of action of plant flavonoids against Proteus vulgaris and Staphylococcus aureus. . Phytochemistry. 1987;; 26 2231-4
- 6 Ubeda A,, Esteve M L,, Alkaraz M J,, Cheeseman K H,, Slater T F.. Effects of flavonoids on cytochrome P-450 rat liver microsomes: Inhibition of enzyme activities and protection against peroxidative damage. Phytotherapy Research. 1995;; 9 416-20
- 7 Panthong A,, Kanjanapothi D,, Tuntiwachwuttikul P,, Pancharoen O,, Reutrakul V.. Anti-inflammatory activity of flavonoids. Phytomedicine. 1994;; 1 141-4
- 8 Akiyama T,, Ishida J,, Nakagama S,, Ogawara H,, Watanabe I,, Itoh N et al.. Genistein, a specific inhibitor of tyrosine-specific protein kinases. Journal of Biological Chemistry. 1987;; 262 5592-5
- 9 Bidel C G,, Poirson J.. Composition for the treatment or prevention of herpes. WO. 1995:; 95/09635
- 10 Vlietinck A J,, De Bruyne T,, Apers S,, Pieters L A.. Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Planta Medica. 1998;; 64 97-109
- 11 Lin Y M,, Flavin M T,, Schure R,, Chen F C,, Sidwell R,, Barnard D L et al.. Antiviral activities of biflavonoids. Planta Medica. 1999;; 65 120-5
- 12 Barnard D L,, Smee D F,, Huffman J H,, Meyerson L R,, Sidwell R W.. Antiherpesvirus activity and mode of action of Sp-303, a novel plant flavonoid. Chemotherapy. 1993;; 39 203-11
-
13 Hudson J B..
Antiviral compounds from plants. CRC Press, . Boca Raton:; 1990 - 14 Hayashi K,, Hayashi T,, Otsuka H,, Takeda Y.. Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the anitherpes acyclovir. Journal of Antimicrobial Chemotherapy. 1997;; 39 821-4
- 15 Mitrocotsa D,, Mitaku S,, Demetzos C,, Harvala C,, Mentis A,, Perez S et al.. Bioactive compounds from the buds of Platanus orientalis and isolation of a new kaempferol glycoside. Planta Medica. 1993;; 59 517-20
- 16 Alpert G,, Mazeron M C,, Colimon R,, Plotkin S.. Rapid detection of human cytomegalovirus in the urine of humans. Journal of Infectious Diseases. 1985;; 152 631-3
- 17 Mazeron M C,, Jahn G,, Platcher B.. Monoclonal antibody E-13 (M-810) to human cytomegalovirus recognizes an epitope encoded by exon 2 of the major immediate early gene. Journal of general Virology. 1992;; 3 2699-703
- 18 Axarlis S,, Mentis A,, Demetzos C,, Mitaku S,, Skaltsounis A L,, Marselos M et al.. Antiviral in vitro activity of Hypericum perforatum L. extract on the human cytomegalovirus (HCMV). Phytotherapy Research. 1998;; 12 507-11
Pr. S. Mitaku
Division of Pharmacognosy School of Pharmacy University of Athens
Panepistimiopolis Zografou
Athens 15771
Greece
Email: mitakou@pharm.uoa.gr
Phone: 017274594