Planta Med 2000; 66(4): 372-374
DOI: 10.1055/s-2000-8553
Letter
Georg Thieme Verlag Stuttgart · New York

Antiplatelet Aggregation Principles from Ephemerantha lonchophylla

Chien-Chih Chen1,*, Yu-Lin Huang1 , Che-Ming Teng2
  • 1 National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
  • 2 Department of Pharmacology, National Taiwan University, Taipei, Taiwan, Republic of China
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Bioactivity-directed separation led to the identification of four compounds, viz. denbinobin (1), 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2), 3-methylgigantol (3), and erianthridin (4) from the ethanolic extract of Ephemerantha lonchophylla. Antiplatelet tests were carried out using 4 different aggregation inducers, viz. arachidonic acid (AA), thrombin, collagen and platelet activating factor (PAF). The results indicated that only compounds 2, 3, and 4 exhibited generally significant anti-aggregation activities with that against AA-induced aggregation being most effective. Estimated IC50, values in this regard for 2, 3, and 4 were 24 μM, 30 μM and 9 μM, respectively.

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Prof. Chien-Chih Chen

National Research Institute of Chinese Medicine

No. 155 - 1, Sec. 2, Li Nung St., Peitou

Taipei 11221

Taiwan

Republic of China

Email: ccchen@cma23,nricm.edu.tw

Phone: +886 - 2 - 28264276