Download PDF
Planta Med 2000; 66(4): 364-365
DOI: 10.1055/s-2000-8554
Letter
Georg Thieme Verlag Stuttgart · New York

Agelasine F from a Philippine Agelas sp. Sponge Exhibits in vitro Antituberculosis Activity

Gina C. Mangalindan1 , Meliza T. Talaue1 , Lourdes J. Cruz1 , Scott G. Franzblau2 , Linda B. Adams2 , Adam D. Richardson3 , Chris M. Ireland3 , Gisela P. Concepcion1,*
  • 1 Marine Science Institute, University of the Philippines, Quezon City, Philippines
  • 2 Laboratory Research Branch, National Hansen's Disease Center, Louisiana State University, Baton Rouge, LA, U.S.A.
  • 3 Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, U.S.A.
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Also available at
    Permissions and Reprints

Abstract

Marine sponge samples were collected in Baler, Aurora, Philippines, and extracts were tested for in vitro antituberculosis activity. An orange Agelas sp. sponge yielded the known compound, agelasine F, which inhibited some drug resistant strains of Mycobacterium tuberculosis in vitro at concentrations as low as 3.13 μg/ml. Activity against M. tuberculosis residing within macrophages required concentrations of 13 - 22 μg/ml which was below the IC50 for Vero cells (34 μg/ml).

References

  • 1 Austin  B.. A review: Novel pharmaceutical compounds from marine bacteria.  Journal of Applied Bacteriology. 1989;;  67 461-70
    PubMedSearch in Google Scholar
  • 2 Shen  X,, Perry  T L,, Dunbar  C D,, Kelly-Borges  M,, Hamann  M T.. Debromosceptrin, an alkaloid from the Caribbean sponge Agelas conifera. .  Journal of Natural Products. 1998;;  61 1302-3
    CrossrefPubMedSearch in Google Scholar
  • 3 Collins  L,, Franzblau  S G.. Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium.  Antimicrobial Agents and Chemotherapy. 1997;;  41 1004-9
    PubMedSearch in Google Scholar
  • 4 Wu  H,, Nakamura  H,, Kobayashi  J,, Ohizumi  Y.. Agelasine-E and -F, novel monocyclic diterpenoids with a 9-methyladeninum unit possessing inhibitory effects on Na, K-ATPase isolated from the Okinawan sea sponge Agelas nakamurai Hoshino.  Tetrahedron Letters. 1984;;  25 3719-22
    CrossrefPubMedSearch in Google Scholar
  • 5 Capon  R J,, Faulkner  D J.. Antimicrobial metabolites from a Pacific sponge, Agelas sp.  Journal of the American Chemical Society. 1984;;  106 1819-22
    CrossrefPubMedSearch in Google Scholar
  • 6 Nakamura  H,, Wu  H,, Kobayashi  J,, Kobayashi  M,, Ohizumi  Y,, Hirata  Y.. Agelasidines - Novel hypotauracyamine derivatives from the Okinawan sea sponge Agelas nakamurai Hishino.  Journal of Organic Chemistry. 1985;;  50 2494-7
    CrossrefPubMedSearch in Google Scholar
  • 7 Cantrell  C L,, Lu  T,, Fronczek  F R,, Fischer  N H,, Adams  L B,, Franzblau  S G.. Antimycobacterial cycloartanes from Borrichia frutescens. .  Journal of Natural Products. 1996;;  59 1131-6
    CrossrefPubMedSearch in Google Scholar
  • 8 Skinner  P S,, Furney  S K,, Jacobs  M R,, Klopman  G,, Ellner  J J,, Orme  I M.. A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions.  Antimicrobial Agents and Chemotherapy. 1994;;  38 2557-63
    PubMedSearch in Google Scholar

Gisela P. Concepcion

Marine Science Institute University of the Philippines

Diliman Quezon City 1101

Philippines

Email: giselapc@compass.com.ph

Phone: +632-921-3799

Fax: +632-433-2990