Planta Med 2000; 66(3): 289-291
DOI: 10.1055/s-2000-8567
Letter
Georg Thieme Verlag Stuttgart · New York

Immunomodulating Properties of the Diterpene Andalusol

Antonio Navarro, Beatriz de las Heras, Angel Villar*
  • Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Andalusol [ent-13(16),14-labdadiene-6α,8α,18-triol], a labdane diterpene isolated from an anti-inflammatory extract of the medicinal plant Sideritis foetens Clem. was evaluated for immunomodulating properties. It exhibited a dose-dependent inhibitory effect on the hemolytic activity of the classical complement pathway and also inhibited lymphocyte proliferation induced by concanavalin A at non-cytotoxic concentrations (1 - 100 μM). No effect on the alternative pathway was observed. These results indicate that andalusol has immunosuppressive effects in vitro in addition to its anti-inflammatory activity.

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Prof. Dr. Angel M. Villar
del
Fresno

Departamento de Farmacologia Facultad de Farmacia

Plaza Ramón y Cajal s/n.

28040 Madrid

Spain

Email: amvillar@eucmax.sim.ucm.es

Phone: +34-91-394-1764

Fax: +34-91-394-1608