Planta Med 2000; 66(5): 483-484
DOI: 10.1055/s-2000-8583
Letter
Georg Thieme Verlag Stuttgart · New York

Cytotoxic Triterpene Acids from the Peruvian Medicinal Plant Polylepis racemosa

Catherine C. Neto1 , Abraham J. Vaisberg2 , Bing-Nan Zhou3 , David G. I. Kingston3 , Gerald B. Hammond1,*
  • 1 Department of Chemistry and Biochemistry, University of Massachusetts-Dartmouth, North Dartmouth, MA, U.S.A.
  • 2 Departamento de Microbiologia, Universidad Peruana Cayetano Heredia, Lima, Peru
  • 3 Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, U.S.A.
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6.9 and 8.3 μg/mL respectively.

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Dr. Gerald B. Hammond

Department of Chemistry and Biochemistry University of Massachussetts-Dartmouth

North Dartmouth

MA 02747

U.S.A.

Email: ghammond@umassd.edu

Phone: +1-508-999-9167