Planta Med 2000; 66(5): 478-480
DOI: 10.1055/s-2000-8597
Letter
Georg Thieme Verlag Stuttgart · New York

Oxoaporphine Alkaloids and Quinones from Stephania dinklagei and Evaluation of Their Antiprotozoal Activities

Maria del Rayo Camacho1,*, Geoffrey C. Kirby2 , David C. Warhurst2 , Simon L. Croft2 , J. David Phillipson1
  • 1 Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, U.K.
  • 2 Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, U.K.
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Bioactivity-guided fractionation of Stephania dinklagei yielded six compounds including, two zwitterionic oxoaporphine alkaloids, N-methylliriodendronine, and 2-O,N-dimethylliriodendronine, two oxoaporphine alkaloids, liriodenine, and dicentrinone, one aporphine alkaloid, corydine, and one anthraquinone, aloe-emodin. Apart from corydine, the isolates have not been reported as constituents of S. dinklagei. N-Methylliriodendronine, and 2-O,N-dimethylliriodendronine are reported for the first time as natural products. All isolated compound were tested for antiprotozoal activity and cytotoxic activities in vitro. N-Methylliriodendronine was the most active against L. donovani amastigotes (IC50 = 36.1 μM). Liriodenine showed the highest activity against Leishmania donovani, and Plasmodium falciparum with IC50 values of 26.16 and 15 μM, respectively. Aloe-emodin was the only compound active (IC50 = 14 μM) against T. b. brucei.

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Dr. Maria del
Rayo
Camacho

Department of Pharmaceutical and Biological Chemistry The School of Pharmacy

29-39 Brunswick Square

London WC 1N 1AX

England

Email: mcamacho@ulsop.ac.uk