Antifungal, Antimitotic and Anti-HIV-1 Agents from the Roots of Wikstroemia indica

Abstract

With guidance of Pyricularia oryzae bioassay, daphnoretin (1), (+)-nortrachelogenin (2), genkwanol A (3), wikstrol A (4), wikstrol B (5) and daphnodorin B (6) were isolated from the roots of Wikstroemia indica. Compounds 1 - 6 induced morphological deformation of P. oryzae mycelia with MMDC values of 68.4 ± 1.3, 31.3 ± 1.8, 45.8 ± 0.5, 70.1 ± 2.4, 52.3 ± 0.9 and 73.7 ± 1.6 μM, respectively. Compounds 3 - 6 showed moderate activity against microtubule polymerization with IC₅₀ values of 112 ± 4, 131 ± 3, 184 ± 6 and 142 ± 2 μM in vitro, respectively. Compounds 2, 3, 5 and 6 were moderately active against HIV-1 in vitro. The findings of bioactivity of 1 - 6 support the antifungus, antimitosis and anti-HIV-1 uses for W. indica roots.

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