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Planta Med 2000; 66(6): 569-571
DOI: 10.1055/s-2000-8605
Letter
Georg Thieme Verlag Stuttgart · New York

Inhibition of Mitochondrial Lipid Peroxidation by Bakuchiol, a Meroterpene from Psoralea corylifolia

Hiroyuki Haraguchi1,*, Junji Inoue1 , Yukiyoshi Tamura2 , Kenji Mizutani2
  • 1 Faculty of Engineering, Fukuyama University, Gakuen-cho, Fukuyama, Japan
  • 2 Biology and Chemistry Laboratory, Maruzen Pharmaceutical Co., Ltd., Sanada Takanishi-cho, Fukuyama, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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Abstract

Bakuchiol, a meroterpene isolated from Psoralea corylifolia, prevented mitochondrial lipid peroxidation. Inhibition of oxygen consumption originating in lipid peroxidation was time-dependent. Bakuchiol protected mitochondrial respiratory enzyme activities against both NADPH-dependent and dihydroxyfumarate-induced peroxidation injury. Bakuchiol was shown to be effective to protect mitochondrial functions against oxidative stress.

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Prof. Hiroyuki Haraguchi

Faculty of Engineering Fukuyama University

Gakuen-cho

Fukuyama 729-0292

Japan

Email: haragu@bt.fubt.fukuyama-u.ac.jp

Phone: +81-(0)849-36-2023