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DOI: 10.1055/s-2000-8619
Direct Analysis and Identification of Triterpene Glycosides by LC/MS in Black Cohosh, Cimicifuga racemosa, and in Several Commercially Available Black Cohosh Products
Publikationsverlauf
Publikationsdatum:
31. Dezember 2000 (online)
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Abstract
A method to directly identify triterpene glycosides using reversed-phase liquid chromatography with positive atmospheric pressure chemical ionization mass spectrometry (LC/(+)APCIMS) was developed. Based on the analysis of the molecular weight, fragment ions, selected ion chromatograms, a number of triterpene glycosides, including actein, 27-deoxyactein, cimicfugoside M, and cimicifugoside, from Cimicifuga racemosa were studied. A chromone, cimifugin, from C. foetida was also identified. Cimicifugoside M and cimifugin can specifically serve as indicators for species identification. The method can, therefore, be used to distinguish black cohosh products from among different plant species for quality control purposes.
Key words
Black cohosh - Cimicifuga racemosa - Cimicifuga foetida - Ranunculaceae - LC/MS - APCI - actein - 27-deoxyactein - cimicifugoside M - cimicifugoside - cimifugin
References
- 1 Foster S.. Black cohosh: Cimicifuga racemosa, a literature review. Herbal Gram. 1999;; 45 36-49
- 2 Corsano S,, Piancatelli G,, Panizzi L.. Actenia, principal acttivo dell` Actea racemosa. . Gazz. Chim. Ital.. 1969;; 99 915-32
- 3 Radics L,, Kajtar-Peredy M,, Corsano S,, Standoli L.. Carbon-13 NMR spectra of some polycyclic triterpenoids. Tetrahedron Lett.. 1975;; 48 4287-90
- 4 Piancatelli G.. Nuovi triterpini dall`Actea racemosa. Nota IV. Gazz. Chim. Ital.. 1971;; 101 139-48
- 5 Corsano S,, Mellor J M,, Ourisson G.. The structure of cimigenol. Chem. Comm.. 1965;; 185-6
- 6 Linde H.. Die Inhaltsstoffe von Cimicifuga racemosa. 5. Mitt: 27-Desoxyacetylacteol. Arch. Pharmaz.. 1968;; 301 335-41
-
7 Blumenthal M,, Busse W R,, Goldberg A,, Gruenwald J,, Hall T,, Klein S,, Riggins W,, Rister R S, editors..
The Complete German Commission E Monographs, Therapeutic Guide to Herbal Medicines, American Botanical Council, Austin, Texas, . Integrative Medicine Communications, Boston, Massachusetts; 1998: 90 - 8 Koeda M,, Aoki Y,, Sakurai N,, Nagai M.. Studies on the Chinese crude drug “Shoma”. IX. Three novel cyclolanostanol xylosides, cimicifugosides H-1, H-2 and H-5, from Cimicifuga rhizome. Chem. Pharm. Bull.. 1995;; 43 1167-70
- 9 Kusano A,, Shibano M,, Kitagawa S,, Kusano G,, Nozoe S,, Fushiya S.. Studies on the constituents of Cimicifuga species. XV. Two new diglycosides from the aerial parts of Cimicifuga simplex Wormsk. Chem. Pharm. Bull.. 1994;; 42 1940-3
- 10 Kusano A,, Shibano M,, Kusano G.. Studies on the constituents of Cimicifuga species. XVII. Four new glycosides from the aerial parts of Cimicifuga simplex Wormsk. Chem. Pharm. Bull.. 1995;; 43 1167-70
- 11 Kadota S,, Li J X,, Tanaka K,, Namba T.. Constituents of Cimicifugae rhizoma II. Isolation and structures of new cycloartenol triterpenoids and related compounds from Cimicifuga foetida L. Tetrahedron. 1995;; 51 1143-6
- 12 Kondo Y,, Takemoto T.. The structure of cimifugin, a new bitter principle from Cimicifuga simplex Wormsk. Chem. Pharm. Bull.. 1972;; 20 1940-4
- 13 Baba K,, Hata K,, Kimura Y,, Matsuyama Y.. Chemical studies of Angelica japonica A. Gray. I. On the constituents of the ethyl acetate extract of the root. Chem. Pharm. Bull.. 1981;; 29 2565-70
-
14 Bradley P R..
British Herbal Compendium. British Herbal Medicine Association, Bournemouth, Dorset.; 1992; 1: 34-6
Qunyi Zheng
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